Cancer

Ginger is Much More Than A Spice!

Posted by kgshah on

***Ginger is Much More Than A Spice!

Although well known as a pleasant tasting cooking spice, it is not so widely known that ginger has been used for thousands of years, worldwide, for its numerous potent healing benefits. Ginger is an especially wonderful ally because its healing benefits are particular to so many of our daily health concerns. Probably best known as a superb digestive aid and nausea reliever, ginger also helps heal ulcers, supports cardiovascular health, reduces pain and inflammation, and speeds recovery from colds and flu while reducing fevers.
Additionally, the National Cancer Institute has recently identified ginger as one of the top ten foods offering the highest levels of anti-cancer activity. Most importantly, ginger accomplishes all these without the side effects associated with drugs.
When Paul Schulick, founder and CEO of New Chapter and master herbalist, began his review of ginger research, both its breadth and depth amazed him. Ginger’s benefits are so varied and valuable that Paul regards it as a true “superherb”. From this research, Paul’s best-selling book Ginger: Common Spice and Wonder Drug was born and with it New Chapter’s ginger products.
New Chapter’s 74-acre organic ginger farm, Luna Nueva, rests on the edge of the beautiful, pristine Children’s Rain Forest in Costa Rica. Our farm radiates a lushness and vibrancy that reflects our commitment to environmental preservation. While establishing a farm of this kind was challenging, we felt it was essential to the quality of our products. Most commercial ginger is heavily fumigated, and we needed a consistent, superior-quality supply of organic ginger.
Demeter Certified – Luna Nueva, New Chapter’s organic farm in the rainforests of Costa Rica, is certified biodynamic by Demeter International, the largest certification organization for biodynamic agriculture and the oldest traditional organic certification in Europe. It’s regarded as the highest grade of organic farming in the world and the most difficult to come by. That’s because it requires biodiversity and ecosystem preservation, soil husbandry, livestock integration, prohibition of genetically engineered organisms, and labor-intensive practices that treat the farm as a living, holistic organism.
Ginger’s numerous valuable health benefits:
Supports healthy digestion, offering 180 times the protein digesting power of papaya
Soothes digestion
Contains at least 12 anti-aging constituents that inactivate free radicals*
Supports blood platelet health and cardiovascular function*
Reduces inflammation*
Enhances natural resistance for cold and flu*
Twenty-two known constituents inhibit inflammatory 5-lipoxygenase, supports prostate health*
May increase absorption and utilization of other nutrients and herbs by as much as 2 to 2.5 times*
Truly a benchmark in the industry, New Chapter’s superlative certified organic softgels, ginger capsules, extracts and syrups are unequaled in their purity and potency.
For more information on the amazing health benefits of ginger, read the following article: Ginger is Much More than a Spice!
For more information about New Chapter’s organic ginger products, click on the following products.
Gingerforce Organic Ginger Supercritical GI Tract/Cardio Tonic
Organic Daily Ginger Caps & Extract – Whole-fiber ginger delivers maximal intestinal & protein-digesting benefits
Digestion Organic Ginger Honey Tonic – Potentiates Digestive Function
Organic Ginger Wonder Syrup – Delicious & Versatile Health Tonic
Energizer Green Tea Organic Ginger Tonic – Supports Colon & Cardiovascular Health
Immune Support Echinacea Organic Ginger Tonic – Immune System Support
Stamina-Ginseng Organic Ginger Tonic – Enhances Physical Endurance and Mental Vitality
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. This article is provided for informational use only.

Cancer

Genital Warts

Posted by kgshah on

***Genital Warts

“I am the Grandmother of all growth, all growing things, all life. I am the grandmother of bacteria and viruses as well as plants and animals, fish and insects. When you throb with life these other lives live with you. When your life force ebbs, they live on you, growing grotesque without the check of your immunity.
“Do you feel proud of your sexuality my child? Your immune system thrives on true pride; and fails when subjected to blame and shame, guilt and mortification. Walk tall; smile often; be flexible, let life fill you, and you will have little to fear from most viruses you meet.”
“… for women who exhibit the earliest signs of HPV infection, the best prescription may be no treatment at all,” according to Karyn Herndon at Northwestern University Medical School in Chicago. “Three out of four women in the observation-only group lost their flat warts – a finding that suggests that the body’s immune system can drive the virus into a dormant state.”(1) Women treated with laser removal of cervical warts were twice as likely as untreated women to have precancerous and cancerous changes occur in the following years.
Having an HPV infection is “like having the sniffles,” says Anna-Barbara Moscicki, MD. “It’s an infection your body can usually handle … and get rid of.”(2) In a study of 600 sexually active women aged 13 to 21, half became infected with HPV over a 10 year period; 70% of those women did not develop lesions or warts at all, and only 10% of those who did have lesions were diagnosed with cervical cancer.(3)
Many of the papilloma viruses are non-contagious, but some – especially those that give rise to plantar warts and genital warts (HPV) – are not only contagious, but widespread and stealthy. They are resilient enough to live outside the body. Shed skin cells containing the viruses can remain infectious for several days in warm, moist places.(4) And symptomless people can pass HPV to others. Some of the viruses that cause genital warts are benign; others can give rise to deadly cancers.
Of the 20 types of HPV which colonize the genital area, four are known to initiate cervical cancer, a usually slow-growing cancer which is currently responsible for the deaths of more women in Africa, Asia, and India (where Pap smears are not routine) than any other cancer.(5) Several HPV are implicated in penile and rectal cancer as well. HPV is the most common STD in the USA and Europe, with more than six million new cases a year in the USA.(6) At least 50%, and probably closer to 100% of all non-vaccinated sexually-active people will be infected over their lifetime. During a three-year study, 40% of a group of female college students acquired HPV infections.(7) Fortunately, only a small percentage of HPV infections generate cancer, and we can do much to insure we aren’t in that small percent.
Once infected with human papilloma virus, you are infected for life. There is no known cure and no medically-approved treatment. The best strategy is to nourish the immune system.
Homeopathic Thuja is a “ground remedy” for the genitals, and is especially indicated when there are genital warts.(8) Higher dilutions, such as 30C, are best.
While there is no food that prevents or cures HPV infections, the likelihood of warts or cancer is determined by the immune system – which can be nourished and strengthened with whole grains, well-cooked greens, roots, cabbage family plants, olive oil, organic dairy products and meats, onions, garlic, seaweed, mushrooms, and nourishing herbal infusions of astragalus, burdock, and nettle.
St. Joan’s wort (Hypericum perforatum) is a natural antiviral. One of its alkaloids, pseudo-hypericin, kills HIV. But ingesting it in concentrated form causes hypersensitivity to sunlight, making it useless as a drug. Fortunately, the tincture of the fresh plant – even in large, frequent doses – counters viruses without triggering sensitivity. Avoid capsules or teas; they can cause sensitivity. When I feel the need to prevent a viral infection, I use one dropperful of Hypericum tincture in a little water three or four times a day for a few days. When I want to treat viral infections, I use one or two dropperfuls in water every hour or two until symptoms abate, and continue at a lower dose until I no longer need it.
Lemon balm (Melissa officinalis) and hyssop (Hyssopus officinalis) are mint family plants with antiviral constituents which are especially effective as salves.
Celandine (Celadonium majus) juice is the most effective way I know to remove external genital warts. It is safe, painless, and easy to use if you live where evergreen celandine grows – in Europe, in North America, from Nova Scotia to Georgia and west to Missouri, throughout Europe, and in waste places in temperate-zone cities. The fresh sap from leaf stalks or the root works fastest, and best, but topical applications of tincture are somewhat effective, too.
American mandrake (Podophyllum peltatum) is the acknowledged queen of external genital wart destruction. This poisonous plant is used in a concentrated form – Podophyllin – as a topical treatment. Although plant-based, Podophyllin can cause severe side-effects, including burns that scar, fatal reactions, and birth defects or fetal death if used during pregnancy. To prevent damage to healthy tissues, all skin except for the warts must be thoroughly covered with petroleum jelly before it is applied, and the Podophyllin must be wiped off before it penetrates too deeply, usually within one to four hours. Weekly treatments over six or more weeks are the norm. A less concentrated, and thus safer form – Podofilox – is available by prescription for use at home. (But trichloroacetic acid is safer, and celandine is more fun.)
Eastern white cedar, Thuja occidentalis, is the “tree of life.” Thuja is primarily a homeopathic remedy, but thuja tincture or essential oil applied twice a day to genital warts can “burn” them off.
Trichloroacetic acid is as effective as Podophyllin in removing warts, but less likely to leave scars or provoke severe systemic reactions, and is considered safe to use during pregnancy.(9) It is applied in the doctor’s office, usually weekly for six weeks.
Colposcopy is a close examination of the cervix with magnifying binoculars after it has been bathed with acetic acid (vinegar), which turns HPV-infected tissues bright white. You do not have to agree to a biopsy if you agree to a colposcopy; testing for HPV-DNA is better in many ways. If you do agree, biopsy forceps will be used to “chomp” out pieces of cervical tissue for microscopic examination by a pathologist.
Testing cervical cells for the presence of DNA from cancer-causing HPV is “just as effective as a biopsy of cervical tissue, with less expense,” according to researchers at Georgetown University Medical Center in Washington, DC. Screening every woman over 20 every two years with an HPV-DNA test would reduce the number of cervical biopsies by 60%, they conclude.(10) A woman who tests negative for HPV, as 45% of women will, does not need a colposcopy. If the test if positive for HPV, there’s still only a 10-20% chance that she will require treatment.(11)
“It is not known how many women who have had expensive [and painful] laser surgery or … cryosurgery are informed beforehand that the treatment is purely cosmetic and has a high recurrence rate.”(12)
Before you agree to any procedure, remember that removal of infected tissue does not remove the virus, which remains ready to recur when the immune system is at an ebb. Surgery doesn’t cure HPV, and because it is a major stress to the immune system, it can increase the chances that a given lesion will progress to cancer.
“Regardless of treatment, one in four HPV-infected people will have a recurrence within three months.”(13)

 

Footnotes:
1. “The cervical dilemma: Some warts may be better left untreated,” Kathy A. Fackelmann, Science News, 139: 362 3, June 8, 1991

2. “HPV doesn’t have to spell cancer,” Christie Aschwanden, Health, Jan/Feb 2002

3. Ibid

4. “Contagion: A sometimes lethal sexual epidemic that condoms can’t stop,” Jerome Groopman, New Yorker, September 13, 1999

5. “Contagion,” Jerome Groopman, New Yorker, 1999

6. “FDA licenses new vaccine …,” FDA news release, June 2006

7. “Contagion,” Jerome Groopman, New Yorker, 1999

8. Natural Healing in Gynecology, Rina Nissim, Pandora, 1984 (p. 43)

9. Our Bodies, Ourselves, Boston Women’s Health Book Collective, 1998

10. “Adding an HPV,” Cornell Uni. Women’s Health Advisor, July 2002

11. “One Way to Avoid Unnecessary Testing After Ambiguous Pap Results,” HealthFacts, May 2001

12. “Screening for Cervical Cancer,” HealthFacts, XV (136), Sept 1990

13. PDR Family Guide to Women’s Health, Medical Economics, 1994

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Cancer

Cortisol, Telomere Length, and Stress

Posted by kgshah on

***Cortisol, Telomere Length, and Stress

In the 1920s, American physiologist Walter Cannon was the first to describe the “fight or flight” response wherein stress hormones prepare our bodies for battle, or give sufficient energy and speed for us to flee from danger (Cannon 1915). Hans Selye (1907-1982), however, is considered to be the father of stress research, and was one of the earliest scientists who published numerous manuscripts on stress, the hormone cortisol, and their impact on health and disease in the early decades of the 20th century. Selye authored the book Stress without Distress, where he called stress “the spice of life” (Selye 1974). Selye recognized stress had positive values when integrated properly into life, but also recognized that an improper reaction to stress in life was a major cause of disease, and that cortisol moderated these effects (Selye 1954).
Cortisol is a hormone that is secreted by the adrenal glands which are located atop the kidneys. Cortisol and noradrenaline initiate a stress response, known as “the fight or flight response”. A massive burst of energy and feelings of alertness follow the release of cortisol into the bloodstream. This physiologic event is fueled by dramatic increases in respiration and increased levels of glucose in the blood stream, which allows the muscles to work harder, faster and for a longer periods of time. This response has one purpose: to get you out of harm’s way. Classic examples could be avoiding an approaching vehicle or escaping from predators.
For most of us the word stress has intrinsically negative connotations. The stress response enables an individual to deal with the stressor (stress causing event), whatever it may be. Stress is an“experience accompanied by predictable biochemical, physiological, cognitive, and behavioral changes that are directed either toward altering the stressful event or accommodating to its effects” (Taylor 2010). Stress can be positive or negative depending on individual context. Cortisol is beneficial only while the dangerous stressing event is present: it makes you alert in the workplace, it aids your concentration and overall sharpens your mental and physical faculties. The problem is that it has been known for decades that elevated and prolonged cortisol levels present health risks which cannot be understated.
Since Selye’s research beginning in the mid-thirties, scientific evidence has supported the hypothesis that chronic stress results in long term chemical changes in the body which manifest themselves in conditions such as, heart and arterial disease, diabetes, high blood pressure, immunosuppression, obesity and increased body mass index (BMI), neuron damage, insomnia, depression, increased risk of suicide, osteoporosis, dementia and Alzheimer’s disease. The latter two may be caused by cortisol-associated damage to the hippocampus (the area of the brain associated with memory processing and organization). In fact, researchers have found that prolonged elevations of cortisol literally caused brain shrinkage (reduced hippocampal volume) and memory deficits compared to individuals with normal cortisol levels (Lupien 1998). This does not suggest that the stress response is in itself dangerous or life threatening. As stated above, the stress response is essential to our survival. For humans the very real danger is that stress is unavoidable and that each stressing event instigates the same response: cortisol is secreted by the adrenal glands in times of emotional stress. The stressor and subsequent release of cortisol can be unrelenting, and may last for extended periods of time. Accumulated cycles of cortisol release can lead to adrenal exhaustion from excess depletion of the adrenal hormones during long-term stress, or alternately to cortisol resistance where cortisol levels are dangerously physiologically high in the bloodstream, but at low levels within the cell. Cortisol resistance may lead to a curious combination of both fatigue and agitation (Cohen et al 2012, and Menke et al 2012). Some examples of long-term stressors could be a messy divorce, an ongoing conflict in the workplace, or even the stress of the daily rush hour each morning and afternoon. The list is endless, and we all have different triggers. It is not always the stressor, but how we as individuals react to that stressor. Each person’s reaction to the same stressor can be remarkably different. For this reason alone, “stress has long been suspected in the etiology [study of causation] of many diseases, and can be immunosuppressive and hence may be detrimental to health” (Dhaber and Mckewen 1999). The basic inference is that after the stressing event has passed, the body needs time to breakdown the stress hormones circulating in our blood stream into harmless substances. If the body does not have the metabolic efficiency or the time to do this effectively, cortisol subsequently will become a toxin. The time taken for cortisol to turn from beneficial (where we feel energized, and elated) to bad (where we feel wired, jittery, and fatigued) has been called, “the cortisol switch” and has been measured at approximately 16 minutes. (Gottfried 2012)
The action of cortisol in the blood stream is analogous to the “oxygen debt” where aerobic respiration enables the body to function at its peak; overstepping this peak initiates anaerobic (oxygen-free) respiration in the muscles. The result of this anaerobic respiration is a build-up of lactic acid: we recognize this by feeling an increased heaviness and tiredness in the muscles, accompanied by progressively more rapid and deeper breathing. There comes a point where you have to stop the activity and pay back the “oxygen debt” by inhaling large amounts of oxygen, and allowing the lactic acid to be transported by the circulatory system to the liver where it is oxidized to carbon dioxide and water. Similarly, we must be removed from a stressing event, or learn adequate coping mechanisms to react to the stressing event in a more healthy fashion in order to allow cortisol levels to return to normal. If this is not accomplished, cortisol levels remain elevated and can quickly become deadly.
Cortisol is unique among hormones because it is the only hormone whose concentration in the body increases as we age. Part of the reason for this is that younger people metabolize (breakdown) the hormone more rapidly than older people. So if our lives are overly stressful for an extended period of time the result is elevated levels of cortisol which effectively have nowhere to go. In essence, the body fails to ensure that cortisol levels rapidly return to normal and remain within homeostatic limits.
In Chronically stressed persons the body simply does not have the time to recover and re-energize after a expereincing a stressful event, because the body is in a near constant state of alertness or “stress-response mode”. Speaking personally [Mark] my last teaching job resulted in an incredibly painful knot in the pit of my belly on a Friday, that did not fully subside until Sunday, just in time for the whole cycle to start again. This is just one of the many symptoms that fall under the category of adrenal fatigue (i.e. resulting from stress and not a pathological condition such as Addison’s disease). The end result is a complete breakdown of the normal stress response and the transformation of a beneficial substance (short term) into a toxin (long term). Some of the long term implications for cortisol’s effect on cellular metabolism are discussed below.
On the tips of our chromosomes, which contain our DNA, located in the nucleus of every cell in our body (aside from red blood cells), lies a structure called a telomere. Telomeres have protective and stabilizing functions. A telomere is like the plastic cap at the end of a shoelace, which keeps the shoelace from unraveling. With each cell division the length of the telomere is reduced, so as we age the telomeres on all of our chromosomes progressively shorten. Eventually, when telomere length is greatly reduced, a condition called cell senescence occurs; the cell is metabolically active but is incapable of division. Research over the last decade provides a picture of how “at the cellular level, stress may promote earlier onset of age-related disease”, (Epal et al. 2004). This research suggests that the stress response has a detrimental effect on cell metabolism, and in particular cell division (mitosis). Equally concerning is the stress response (i.e. cortisol) effect on telomere length and consequently on cell longevity. Cortisol has a destructive effect on the enzyme telomerase which “relengthens the telomeres so that they get the same length as before embarking on cell division” (Bojesen et al 2013). Research shows that chronic stress can subtract 10 years to your lifespan. The cell’s environment directly regulates both the activity of telomerase and telomere length with profound consequences such that chronic stress is associated with “telomeres shorter on average by the equivalent of at least one decade of additional aging” (Epal et al 2004), as compared with less stressed persons. There is now a significant body of research documenting the detrimental effect of ether stress (or the associated release of cortisol during stress) on telomere shortening (Daubenmier et al. 2012; Tomiyama et al 2012; Parks et al 2009). When the telomere length is zero, cell apoptosis (self-suicide) occurs. Therefore, telomere length is one of the determining factors of cell longevity and senescence. Reduced telomere length has been associated with high death rates in elderly people. The implication is that elevated and persistent cortisol levels accelerate this process such that the mapping of telomeres has profound implications for the cellular basis of chronic stress and age related diseases, in addition to boosting understanding regarding cancers, the appropriate treatment of those cancers, and the genetic links between telomere length and the subsequent development of cancer. (Bojesen et al 2013).
Any high school biology book or fitness schedule tells us that a balanced diet is essential for overall health and well-being. If it is impossible to avoid the stressing events, is it possible to alleviate the impact of elevated cortisol levels, or is it possible to block stress response pathways? In essence we are asking if it is possible to inhibit the production of cortisol. Research and clinical trials since the mid-nineties have shown that a substance derived from the whites of fertilized chicken eggs called Young Tissue Extract, or YTE, may play a crucial role in reducing cortisol levels in young as well as in elderly subjects, and thus this substance may play a role in stress management. It is important to clarify that YTE does not inhibit normal stress response but, “restores the ability of chronically stressed subjects to adapt to acute stress” (Schult et al 2009).
YTE is marketed internationally under the name Laminine, and because it is not a prescription drug, but is a nutritional supplement, the manufacturer cannot make any claims for the prevention, mitigation, treatment, or cure of any disease. The freeze-dried supplement does contain a combination of essential amino acids, peptides and growth factors which have been shown to elevate levels of a substance called 17-ketosteroid. This steroid (a critically important class of biological molecule) has many functions, but one result of ingestion is, that it reduces the rate of the body’s production of cortisol. Laminine has been shown to inhibit the stress response by elevating the body’s production of serotonin, which promotes feelings of wellbeing and relaxation (Solberg 2011). Effectively, our stress hormone levels drop because we lose our feelings of anxiety, worry, insecurity and related negative emotions. We all know the short term consequences of stress include insomnia, reduced appetite, feeling overwhelmed or powerless and increased alcohol intake to cope with these feelings. The long-term consequences can be severly debilitating, or even life threatening. It is important to note that chronic stress should be avoided at all costs, however, sometimes this is just not possible and it may be unrealistic to say, “just remove the stressing event”. For persons enduring an extended stressful period Laminine may be an answer as people who are chronically stressed “profit both psychologically and physiologically from YTE”. (Schult et al 2009), along with proper diet, exercise, stress reduction and relaxation techniques, and the moderation of alcohol (Mendelson et al 1966; Thayer et al 2006; Stalder et al 2010) and coffee intake (Bennett et al 2013), the latter two of which are also associated with elevated cortisol levels.
REFERENCES

* Stig E Bojesen et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 2013; 45 (4): 371 DOI: 10.1038/ng.2566
http://www.nature.com/ng/journal/v45/n4/full/ng.2566.html
http://www.sciencedaily.com/releases/2013/03/130327133341.htm
* Epel et al. Accelerated telomere shortening in response to life stress. PNAS vol. 101 no. 49 December 7, 2004 http://www.pnas.org/content/101/49/17312.full.pdf+html?sid=8afef197-2e32-46e9-b658-2a67bf0dba9c

* Lupien SJ et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature neuroscience. volume 1 no 1: May 1998 http://www.nature.com/neuro/journal/v1/n1/pdf/nn0598_69.pdf
* Taylor S.E. Mechanisms linking early life stress to adult health outcomes. Proceedings of the National Academy of Sciences. Vol. 107, No. 19. May 2010. http://www.pnas.org/content/107/19/8507.full
http://www.pnas.org/content/107/19/8507.full.pdf+html

* Dhaber FS and Mckewen BS. Enhancing versus suppressive effects of stress hormones on skin immune function. Proceedings of the National Academy of Sciences. Vol. 96, No. 3: 1059-1064. February 2, 1999. http://www.pnas.org/content/96/3/1059.full?sid=1f420118-3137-4205-9429-5ca87841ecf7
http://www.pnas.org/content/96/3/1059.full.pdf+html

* Schult J et al. Effects of powdered fertilized egg on the stress response. Clin Nutr. 2010 Apr;29(2):255-60. http://www.ncbi.nlm.nih.gov/pubmed/19837490

* Solberg, E. The Effects of Powdered Fertilized Eggs on Depression. J Med Food. 2011 July; 14(7-8): 870–875. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133680/
* Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, Turner RB. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5995-9. Epub 2012 Apr 2. http://www.ncbi.nlm.nih.gov/pubmed/22474371
* Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients. Neuropsychopharmacology. 2012 Jul;37(8):1972. doi: 10.1038/npp.2012.21. http://www.ncbi.nlm.nih.gov/pubmed/22699688
* Daubenmier J, Lin J, Blackburn E, Hecht FM, Kristeller J, Maninger N, Kuwata M, Bacchetti P, Havel PJ, Epel E. Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study. Psychoneuroendocrinology. 2012 Jul;37(7):917-28. Epub 2011 Dec 14. http://www.ncbi.nlm.nih.gov/pubmed/22169588
* Tomiyama AJ, O’Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E. Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav. 2012 Apr 12;106(1):40-5. Epub 2011 Nov 28. http://www.ncbi.nlm.nih.gov/pubmed/22138440
* Parks CG, Miller DB, McCanlies EC, Cawthon RM, Andrew ME, DeRoo LA, Sandler DP. Cancer Epidemiol Biomarkers Prev. Telomere length, current perceived stress, and urinary stress hormones in women. 2009 Feb;18(2):551-60. Epub 2009 Feb 3. http://www.ncbi.nlm.nih.gov/pubmed/19190150
* Selye H. Interactions between systemic and local stress. British Medical Journal. 1954 May 22;1(4872):1167-1170. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2085130/?page=1
* Selye H. Stress without distress. Philadelphia: Lippincott, 1974.
* Mendelson, Jack; Stein, Stefan. Serum Cortisol Levels in Alcoholic and Nonalcoholic Subjects During Experimentally Induced Ethanol Intoxication. Psychosomatic Medicine 28 (4): 616–26. 1966.
* Thayer, Julian F.; Hall, Martica; Sollers, John J.; Fischer, Joachim E. Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers. International Journal of Psychophysiology 59 (3): 244–50. 2006. doi:10.1016/j.ijpsycho.2005.10.013. PMID 16325293.
* Stalder, Tobias; Kirschbaum, Clemens; Heinze, Kareen; Steudte, Susann; Foley, Paul; Tietze, Antje; Dettenborn, Lucia. Use of hair cortisol analysis to detect hypercortisolism during active drinking phases in alcohol-dependent individuals. Biological Psychology 85 (3): 357–60. 2010. doi:10.1016/j.biopsycho.2010.08.005. PMID 20727937.
* Fisone G, Borgkvist A, Usiello A . Caffeine as a psychomotor stimulant: mechanism of action. Cell. Mol. Life Sci. 61 (7–8): 857–72. 2004. doi:10.1007/s00018-003-3269-3. PMID: 15095008
* Bennett JM, Rodrigues IM, Klein LC. Effects of Caffeine and Stress on Biomarkers of Cardiovascular Disease in Healthy Men and Women with a Family History of Hypertension. Stress Health. 2013 Mar 18. doi: 10.1002/smi.2486. PMID: 23504818
* Gottfried S. Cortisol Switcharoo: How Cortisol Makes You Fat and Angry, Plus 7 Practices to Rock Your Stress. http://www.saragottfriedmd.com/2012/05/04/cortisol-switcharoo/# May 4, 2012 (Accessed May 27, 2013)
* Eliot, RS. Is it worth dying for? How to make stress work for you – not against you. Bantam Books. NY, NY. 1984.
* Walter Bradford Cannon. Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches into the Function of Emotional Excitement. Appleton-Century-Crofts. 1915.

Breast Cancer/Cancer

Breast Cancer and PEMF Therapy

Posted by kgshah on

***Breast Cancer and PEMF Therapy

Since many anticancer therapies are very general in their action of killing cancer cells and have dramatic side effects, different, effective, yet less toxic, approaches to treating cancers are necessary.
I previously reported on a study that looked at the use of pulsed electric fields on breast cancer in mice. Electric fields have both an electric and magnetic aspect to them. Very short pulse length pulsed electric fields, which don’t create heating to destroy tissue, were used. The frequency was 4 hertz. Two weeks after treatment, the growth of treated tumors was inhibited by 79%. MRI was used to assess the physical changes in the tumors. Various growth factors, including the development of new blood vessels, were strongly suppressed. As a control, normal skin was treated the same way as the tumors and showed no permanent changes. So, breast cancer tumors react differently to PEMFs, with a desirable cancer suppressive reaction, than normal tissue does. These results suggest that electromagnetic fields may be able to inhibit human breast cancer development and suppress tumor blood vessel growth, and may therefore serve as a new approach to the treatment for breast cancer.
New Study
In a new study, the authors studied the potential for ultra-low intensity and frequency PEMFs to kill breast cancer cells. They wanted to see if the PEMFs in question could show: 1) toxicity to breast cancer cells and; 2) and they were not harmful to healthy cells. Breast cancer cells and normal cells were exposed to PEMFs and cell death indices were measured to determine which PEMFs best kill breast cancer cells. The PEMF parameters tested were: 1) frequencies ranging from 20 to 50 Hz; 2) intensities ranging from 2 mT (20 Gauss) to 5 mT (50 Gauss) and; 3) exposure times ranging from 30-90 minutes per day for up to three days. These were to determine the optimum parameters for selective cancer cell killing. At the end of the study they found a discrete optimal window of vulnerability of breast cancer cells to PEMFs of 20 Hz frequency, 3 mT (30 Gauss) magnetic field intensity and exposure duration of 60 minutes per day. PEMFs applied at a repetition rate of 50 Hz did not produce any noticeable effects on cell viability. The amount of cell damage seen in response to PEMFs increased with time and was even more significant after three days of consecutive daily exposures. By contrast, the optimal PEMF usage found to be the most damaging to breast cancer cells was not damaging to normal cells, and were in fact slightly enhancing to normal cell function. However, based on the evidence from this study, other exposure times (that is, 90 minutes) and intensities 2 mT and 5 mT) were still very strongly effective for killing breast cancer cells, even though not optimal. That means that 20 Gauss and 50 Gauss PEMFs were also quite effective and both 60 minutes and 90 minute exposures were also effective.
A clear window of vulnerability of cancer cells to PEMFs exists; more is not necessarily better. That weaker fields, or less exposure to them, are less lethal, upon first impression, might seem somewhat intuitive. However, the fact that stronger, or longer, exposure to fields is less efficient at killing, implies some specificity of biological action, rather than a straightforward dose-dependent accumulation of generalized damage over susceptible cells. The most directly measurable effect of PEMFs on breast cancer cells in this study is that of induced cancer cell death (the medical term is apoptosis). Nonetheless, never mind cell death, even the capacity of PEMFs to slow the growth of a cancer cell also would be a positive clinical outcome and of relevance in advancing PEMF-based anti-cancer therapies.
Mechanisms in Play
The question becomes what is the mechanism of action of PEMFs in the killing of cancer cells. A commonly reported result of PEMF exposure is elevation of intracellular calcium level. In the context of the current study, 3 mT PEMFs at a frequency of 20 Hz for 60 minutes per day would create the “correct” combination of calcium signals that would most effectively result in cell death. Indeed, it has been shown in other studies that augmenting intracellular calcium compromises cancer cell survival.
Non-malignant cells are unaffected, or even fortified, by the PEMFs used in this study. Therefore, based on this research, using PEMF-based technologies, the greatest damage is done in breast cancer cells, supporting the possibility that it may be ultimately feasible to selectively remove cancer cells from an organism without damaging normal tissues. The apparent lack of response of normal cells to PEMFs might suggest that their internal calcium control mechanisms are capable of balancing, or even exploiting, small increases in intracellular calcium concentrations. Breast cancer cells appear to not be able to withstand even modest changes in intracellular calcium levels. This conclusion is supported by other recently published studies.
While this study was done outside a human body, it lends very strong support to the possibility that breast cancer cells may be impacted in a healthy direction, while sparing surrounding normal cells. While it is not certain from this study whether these results would be best seen in the setting of actual cancer in humans or to prevent the development of cancer is still unknown. Since this research seems to indicate, as does much other research, that PEMFs do not seem to affect healthy cells in any negative way, PEMFs may be a very useful tool in both treating and preventing breast cancer.
Conclusion
Because we don’t have definitive research data to support this concept, I would not normally recommend using PEMF therapies as a sole solution. However, for those individuals who are not candidates for conventional therapies or whose personal preferences prevent them from using conventional therapies, PEMFs may well be a good alternative. I think this may certainly apply itself well to the case of ductal carcinoma in situ [DCIS] of the breast, which is not considered a cancer, but rather a pre-cancer. A large percentage of women with DCIS never actually convert their DCIS process into actual cancer. Since conventional medicine cannot predict who will convert and who won’t, at this point, conventional medical practice treats these as cancers, which results in a significant risk of overtreatment for a lot of women. Again, PEMFs may well be a good alternative in this situation and the progress of the breast changes in DCIS may be monitored over time and if progression is confirmed, then more aggressive therapeutic measures may be applied.
The most important take away from these two studies is that PEMFs might prove useful as a non-invasive, additional treatment to be combined with other common anti-cancer therapies. Based on this data it appears that PEMF-based anticancer strategies may represent a new therapeutic approach to treat breast cancer without affecting normal tissues and is done in a manner that is non-invasive.
REF:
Wu S, Wang Y, Guo J, Chen Q, Zhang J, Fang J. Nanosecond pulsed electric fields as a novel drug free therapy for breast cancer: An in vivo study. Cancer Lett. 2013 Oct 4. S0304-3835(13)00701-5.
Low intensity and frequency pulsed electromagnetic fields selectively impair breast cancer cell viability. Crocetti S(1), Beyer C, Schade G, Egli M, Fröhlich J, Franco-Obregón A. PLoS One. 2013 Sep 11;8(9).

Cancer

Bioctive whey protein and its role in enhancing glutathione levels

Posted by kgshah on

***Bioctive whey protein and its role in enhancing glutathione levels

Bio-active whey protein refers to a mixture of globular proteins that are recovered from whey, the liquid by product obtained during cheese production (Smilkov, et al., 2013) . The protein composition in cow milk is 80% casein protein and 20% whey protein. Whey protein makes up 10% of whey’s dry weight. The protein is often made up of beta-lactoglobulin (65%), alpha-lactalbumin (25%), bovine serum albumin (8%), and immunoglobulins (Smilkov, et al., 2013) . A number of preclinical studies conducted in rodents have shown that whey protein might possess some anti-cancer and ant-inflammatory properties. Other studies have shown that the protein might have an effect on muscle growth, though this observation is debatable. Researchers are currently trying to understand if whey protein has any impact on human health (Smilkov, et al., 2013) .
Whey protein has been marketed as a dietary supplement under the name Immunocal (HMS-90). The name Immunocal is derived from the immune system effects. The supplement is globally marketed and sold as an all-natural non-prescription health product (Immunocal Health Benefits, 2013) . The protein holds several international patents and is medically recognized by several physician bodies around the globe, including the Physicians’ Desk Reference (“PDR” U.S.A) and the Compendium of Pharmaceutical Specialties (“CPS” Canada) (Immunocal Health Benefits, 2013) . Immunocal’s health benefits include providing the body with much needed amino acids, and raising glutathione levels (Immunocal Health Benefits, 2013) . According to unverified data, Immunocal provides cysteine, a glutathione precursor that is vital in the maintenance of a strong immune system (Immunocal Health Benefits, 2013) .
Glutathione (GSH) can be described as a tripeptide formed by gamma peptide linkages between the glutamate side-chain carboxyl group and the amine group of cysteine (Lupton, 2004) . Glutathione works as an antioxidant, and prevents damage to vital cell components as a result of reactive oxygen, including peroxides and free radicals. GSH is widely regarded as the master antioxidant in cellular defense (Lupton, 2004) . It also plays a vital role in the a number of cellular events including gene expression, cell proliferation and apoptosis, signal transduction, DNA and protein synthesis, cytokine production and immune response, and protein glutathionylation (Lupton, 2004) .
The tripeptide is produced by the liver and is able to function as an antioxidant in the lungs, Red blood cells, liver and the intestinal tract. It also helps in the removal of a wide range of toxins including those that come from heavy metals, cigarette smoking, alcohol, cancer chemotherapy and radiation (Lupton, 2004) .
In mammalian cells GSH concentrations range from 1 to 10mM, though reduced concentrations predominate over the oxidized form (GSSG). Studies indicate the maintenance of optimal ratios of GSH: GSSG is critical for survival, and the deficiency results into oxidative damage (Lupton, 2004) . GSH plays a critical role in the prevntion and control of a number of disorders, including autoimmune diseases, neurodegenerative diseases, diabetes and cancer (Lupton, 2004) .
Several molecular studies have been carried out to understand the interactions between specific whey proteins and tumor cells. In 1999, Svensson et al. conducted a molecular characterization of alpha-lactalbumin folding varriants that induce apoptosis in tumor cells but spare healthy cells (Svensson, et al., 1999) . Purification of the active fraction from other casein components was carried out by anion exchange chromatography, it was then retained by ion exchange and eluted after a high salt ingredient (Svensson, et al., 1999) . The active fraction was indicative of an N-terminal amino acid seqence identical to human milk alpha-lactalbumin, and post-translational modifications were ruled out by mass spectrometry (Svensson, et al., 1999) . Oligomers with high molecular weight exhibited kinetic stability and were found to have an essentially retained secondary structure but a less organized tertiary structure (Svensson, et al., 1999) . On comparison with native monomeric and molten globule alpha-lactalbumin, it was established that the active fraction contained oligomers of alpha-lactalbumin that have undergone a conformational switch toward a molten globule-like state (Svensson, et al., 1999) . The findings of the study suggested that there might be differences in biological properties between folding variants of alpha-lactalbumin (Svensson, et al., 1999) .
There are various studies that indicate a role by bio-active whey protein on the level of glutathione. A study was conducted by Baruchel and Viau to investigate the in vitro selective modulation of cellular glutathione by humanized native milk protein isolate in normal cells and rat mammary carcinoma(1996) . The study utilzed immunocal to establish the inhibitory activity of whey protein on mammary cell carcinoma cells and Jurkat T cells (Baruchel & Viau, 1996) . This was compared to normal peripheral blood mononuclear cells and related to the inhibitory activity to a selective depletion of intracellular glutathione sysnthesis (Baruchel & Viau, 1996) . The findings of the study showed that the use of humanized whey as food supplementation may have a direct impact on a clinical trial with adjuvant chemotherapy
A review conducted by Ross et al. focused on Immunocal and preservation of glutathione as a novel neuroprotective strategy for degenerative disorders of the nervous system (2012) . The study was based on the background that oxidative stress and glutathione (GSH) depletion are both established as key contributing factors to the pathogenesis of many devastating neurodegenerative diseases as a of free radical generation (Ross, Gray, Winter, & Linseman, 2012) . According to the study, strategies that increase or preserve levels of intracellular glutathione have been demonstrated to act in a neuroprotective manner, indicating that the augmentation of available GSH pool may be a promising therapeutic target for neurodegeneration (Ross, Gray, Winter, & Linseman, 2012) . The review discussed the capacity of cystine-rich, whey protein supplement (Immunocal) to enhance the de novo synthesis of GSH in neurons, and highlighted its potential therapeutic use in the mitigation of oxidative damage which forms a key component in the pathogenesis of various neurodegenerative diseases (Ross, Gray, Winter, & Linseman, 2012) .
The increasing knowledge on the impact of whey protein on the levels of GSH, has prompted a number of clinical trials to investigate how this works in various neurodegenerative diseases. An open-label clinical trial was conducted by Kern et al. to investigate the effects of using a cysteine-rich protein isolate in children with autism (Kern, Grannenmann, Gutman, & Trivedi, 2008) . The study was partly based on findings that show low levels of glutathione in children suffering autism, and that non-denatured whey protein could positively impact on glutathione levels (Kern, Grannenmann, Gutman, & Trivedi, 2008) . A preliminary investigation showed that many children with autism could easily feed on non-denatured whey protein isolate (immunocal) without experiencing any problems (Kern, Grannenmann, Gutman, & Trivedi, 2008) .
During the study, a 6-week open-label trial was conducted , in which 10 children with autism or autism spectrum disorder (ASD), aged between 3-15 years, were supplemented with NWPI (Immunocal) (Kern, Grannenmann, Gutman, & Trivedi, 2008) . Several procedures that measured the frequency and intensity of various side effects were completed at baseline (Kern, Grannenmann, Gutman, & Trivedi, 2008) .The findings of the study showed that seven out of ten children who took the supplement tolerated it well (Kern, Grannenmann, Gutman, & Trivedi, 2008) . Two children were discontinued due to possibe side effects, while another was discontinued due to challenges experienced in the adminstration of the supplement. (Kern, Grannenmann, Gutman, & Trivedi, 2008) . The fiindings of the study suggested that Immunocal can be used in a number of autistic children without raising the risk of possible side effects. However, further investigations were recommended to establish the efficacy in larger populations (Kern, Grannenmann, Gutman, & Trivedi, 2008) .
Other studies have shown that Immunocal may cause the depletion of GSH in cancer cells and, therefore, facilitate chemotherapy. A study conducted by Kennedy et al. in 1995 seemed to suggest that whey protein causes depletion of high glutathione (GSH) levels in tumor cells. The study investigated on the use of whey protein concentrate in the treatment of patients with metastatic carcinoma (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) . The study was based on the belief that the high levels of glutathione concentration in tumor cells may have a role in resistance against chemotherapy. According to the study, a number of in-vitro assays showed that concentrations that induce GSH synthesis in normal human cells, a specially prepared whey protein concentrate, Immunocal, caused GSH depletion and, therefore, caused the inhibition of the growth of human breast cancer cells (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) . On the basis of this background, five patients suffering from metastatic breast carcinoma, one with metastatic carcinoma of the liver, and one with metastatic carcinoma of the pancreas, were fed on 30 grams of whey protein concentrate daily for a period of six months (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) . In six of the patients included in the study, the blood lymphocyte GSH levels were found to be substantially high on the onset, indicating a high tumor GSH levels (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) . Two of the patients showed signs of tumor regression, normalization of hemoglobin and peripheral lymphocyte counts and steep drop in the level of GSH in lymphocytes towards normal levels (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) . Two patients showed a stabilized tumor and increased hemoglobin levels, while in three of the patients the disease was seen to progress with a trend toward higher levels of GSH in lymphocytes (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) . The results of the study seem to indicate that whey protein concentrate might deplete tumor cells of GSH and render them more vulnerable to chemotherapy (Kennedyy, Konok, Bounous, Baruchel, & Lee, 1995) .
Another study was conducted by Tsai et al. to investigate on the effect of patented whey protein isolate (Immunocal) on cytotoxicity of an anticancer drug (2000) . The human hepaloma cell line Hep G2 were left to grow in different media for four days, and cell apoptosis used to investigate the enhancing effect of whey protein on the cytotoxicity of a potential anticancer drug, baicalein (Tsai, Chang, Chen, & Lu, 2000) . The control groups were cultured in normal medium, while the other three groups were grown in Immunocal medium, baicalein medium, and a combination of Immunocal and baicalein (Tsai, Chang, Chen, & Lu, 2000) . The results showed that survival rates were much lower in cells grown in Immunocal and baicalein as compared to those grown in baicalein alone (Tsai, Chang, Chen, & Lu, 2000) . However, no significant differences were observed in the survival rates of cells grown in Immunocal. The researchers also demonstrated that immunocal reduced glutathione (GSH) in Hep G2 cells by a margin of between 20-40% and controlled the elevation of GSH, which was in response to baicalein (Tsai, Chang, Chen, & Lu, 2000) . The researchers concluded that Immunocal enhanced cytotoxicity of baicalein, and the increase in apoptotic cells was linked to the depletion of GSH in Hep G2 cells (Tsai, Chang, Chen, & Lu, 2000) .
Other studies have looked into the effect of Immunocal on glutathione levels in some disease states. A study was conducted by Grey et al. to establish how whey protein supplementation impacted on the status of glutathione in young adult patients suffering from cystic fibrosis (2003) . The study was based on the background that the lung disease of cystic fibrosis is associated with a chronic inflammatory reaction and an over abundance of oxidants to relative antioxidants and, therefore, glutathione was crucial in the prevention of oxidants build-up in the lungs (Grey, Mohammed, Smountas, Bahlool, & Lands, 2003) . Twenty-one patients in stable condition were randomly administered with 10 g of Immunocal twice a day or a casein placebo for period of three months. Peripheral GSH was then utilized as a marker for lung GSH (Grey, Mohammed, Smountas, Bahlool, & Lands, 2003) . At baseline, the researchers did not find any significant differences in age, height, weight, percent body weight or percent ideal height, however, a 46.6% was observed following supplementation(Grey, Mohammed, Smountas, Bahlool, & Lands, 2003) . The findings indicate that dietary supplementation with a whey-based product can enhance glutathione levels in cystic fibrosis (Grey, Mohammed, Smountas, Bahlool, & Lands, 2003) .
A study conducted by Micke et al. investigated on the effects of long-term supplementation with whey proteins on plasma glutathione levels in HIV-infected patients (2002) . The study was based on the background that HIV infections are characterized by an enhanced oxidant burden and systematic deficiency of glutathione (GSH), a key anti-oxidant (Micke, Beeh, & Buhl, 2002) . During the study, up to 30 patients were randomized to a daily dose of 45 g whey proteins of either Protectamin or Immunocal for a period of two weeks. In the patients, the pre-therapy GSH levels were lower than normal, however, following two weeks of whey supplementation, plasma total GSH levels increased in the Protectamin group by 44+/- 56%, while the difference in the Immunocal group remained below significance (Micke, Beeh, & Buhl, 2002) . As a result, all patients in the trial were switched to Protectamin, and six month analysis showed that the total GSH plasma levels were significantly elevated (Micke, Beeh, & Buhl, 2002). The study established that supplementation with whey proteins persistently led to increased plasma levels of GSH in patients with advanced HIV infection (Micke, Beeh, & Buhl, 2002) .
A study was carried out by Watanabe et al to investigate nutritional therapy of chronic hepatitis by non-heated whey protein (2000) . The clinical efficacy of whey (Immunocal) was investigated in 25 patients with chronic hepatitis B or C (Watanabe, et al., 2000) . Casein was given for two weeks prior to Immunocal supplementation. The supplement was provided twice a day, both in the morning and evening for a period of 12 weeks. Investigations showed that Serum alanine aminotransferase (ALT) activity was reduced, while glutathione levels increased in six and five of eight patients diagnosed with chronic hepatitis B respectively (Watanabe, et al., 2000) . The findings of this study suggest that long-term supplement with Immunocal might be effective in enhancing liver functions in patients with chronic hepatitis (Watanabe, et al., 2000) .
Apart from the glutathione use in enhancing the fight against disease states, the oxidant plays a key role in athletic activities. Athletes use muscles more and, therefore, generate a lot of free radicals. Glutathione plays a key role in the elimination of such radicals. A study conducted by Lands et al investigated on the effect of supplementation with a cysteine donor on muscular performance (1999) . The study was based on the knowledge oxidative stress contributes to muscular fatigue, and glutathione is the major intracellular antioxidant that is dependent on the availability of cysteine (Lands, Grey, & Smountas, 1999) . They hypothesized that by giving a whey based supplement ( Immunocal) that is designed to augment intracellular GSH, performance would be improved (Lands, Grey, & Smountas, 1999) . Twenty healthy young adults were studied both pre and post-supplementation with either Immunocal or placebo (Lands, Grey, & Smountas, 1999) . The results showed that GSH increased significantly in the immunocal group, with no change in the placebo group (Lands, Grey, & Smountas, 1999) .
Summary
Glutathione has been established as one of the most important intracellular antioxidant. Whey protein provides cysteine, which is critical in the biosynthesis of glutathione. The studies reviewed indicate that whey protein plays a positive role in enhancing glutathione levels both in healthy and various disease states.

References

Baruchel, S., & Viau, G. (1996). In vitro selective modulation of cellular glutathione by a humanized native milk milk protein isolate in normal cells and rat mammary carcinoma model. Anticancer Res , 16 (3A): 1095-9.
Grey, V., Mohammed, S. R., Smountas, A. A., Bahlool, R., & Lands, L. C. (2003). Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. J Cyst Fibrosis , 2(4):195-8.
Immunocal Health Benefits. (2013). Retrieved August 4, 2013, from What is Immunocal: http://www.whatisimmunocal.com/
Kennedyy, R. S., Konok, G. P., Bounous, G., Baruchel, S., & Lee, T. D. (1995). The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical study. Anticancer , 15(6B):2643-9.
Kern, J. K., Grannenmann, B. D., Gutman, J., & Trivedi, M. H. (2008). Oral Tolerability of Cysteine-Rich Protein Isolate ( Immunocal) in Autism – A pilot Study. Journal of the American Nutraceutica Association , 11(1): 36 -41.
Lands, L. C., Grey, V. L., & Smountas, A. A. (1999). Effect of supplementation with a cysteine donor on muscular performance. J Appl Physiol , 87(4):1381-5.
Lupton, J. R. (2004). Glutathione metabolism and its implications for health . J Nutr , 134(3):489-92.
Micke, P., Beeh, K. M., & Buhl, R. (2002). Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur J Nutr , 41(1):12-8.
Ross, E. K., Gray, J. J., Winter, A. N., & Linseman, D. A. (2012). Immunocal and the preservation of glutathione as a novel neuroprotective strategy for degenerative disorders of the nervous system. Recent Pat CNS Drug Discov , 7(3):230-5.
Smilkov, K., Petreska, T. I., Petrushevska, T. L., Petkovska, R., Hadjieva, J., Popovski, E., et al. (2013). Optimization of the formulation for preparing Lactobacillus casei loaded whey protein-Ca-alginate microparticles using full-factorial design. J Microencapsul .
svensson, M., Sabharwal, H., Hakansson, A., Mossberg, A. K., Liniunas, P., Leffler, H., et al. (1999). Molecular characterization of alpha-lactaibumin folding variants that induce apoptosis in tumor cells. J Biol Chem , 5;274(10):6388-96.
Tsai, W. Y., Chang, W. H., Chen, C. H., & Lu, F. J. (2000). Enchancing effect of patented whey protein isolate (Immunocal) on cytotoxicity of an anticancer drug. Nutr Cancer , 38(2):200-8.
Watanabe, A., Okada, K., Shimizu, Y., Wakabayashi, H., Higuchi, K., Niiya, K., et al. (2000). Nutritional therapy of chronic hepatitis by whey protein (non-heated). J Med , 31 (5-6):283-302.

Cancer

Association between fish oil (Omega-3 fatty acids) and prostate cancer

Posted by kgshah on

Association between fish oil (Omega-3 fatty acids) and prostate cancer

Friends and family members of those fighting cancer often turn to aromatherapy & other types of alternative healing for help and support. It can be extremely frustrating to want to help a friend or loved one battling this terrible disease while feeling powerless to do so. Although certain essential oils (among them Frankincense, a rare species of Cypress, certain varieties of Thyme and Sage, and Lemongrass) have shown possible anti-tumor effects in some laboratory tests & research, to make any claims that essential oils can provide a cure for cancer is at the very least irresponsible and cruel.
What the oils can do, however, is strengthen the spirit, and provide emotional and spiritual support, both for the patient and for family members and caregivers. Essential oils are also being used to alleviate painful side effects of radiation & chemotherapy in cancer patients.
For strengthening the spirit, of particular usefulness are: Frankincense, Rose, & Atlas or Himalayan Cedarwood to spiritually uplift & promote emotional courage & strength. Further, Sandalwood oil, perhaps blended with either Cedarwood or Rose, can be emotionally supportive and comforting. Also, blends of citrus oils or conifers, diffused in the room, or used as an airborne spray does a wonderful job of both lifting the spirits, and removing “sickroom” odors. Some possible choices are: Pink Grapefruit, Sweet Orange, Red Mandarin, or Scotch Pine, Balsam Fir, Cypress, or Juniper.
Health care providers in America are becoming more open to the benefits of the holistic approach in caring for patients, with some adding aromatherapy programs as an element of treatment. This was the case when Nature’s Gift Aromatherapy was recently asked to provide a blend for a hospice in Montana as part of the facilities newly approved aromatherapy program. The nurse aromatherapist who commissioned the blend recommended using it with a gentle hand or foot massage. The blend consisted of 10 drops each of Somalian distilled Frankincense, and Frankincense CO2 extracted, with just 5 drops of Rose Otto 10% dilution. This would be the equivalent of 40 drops of Frankincense to 1 drop of undiluted Rose Otto. The blend may be diffused in an aroma lamp or diffuser or diluted way down (a 1% dilution, 6 drops of the blend to one fluid ounce of carrier oil or lotion) for massage.
On a physical level, positive results are being reported in dealing with post radiation pain and burning by using a blend of Jojoba oil and Aloe Vera gel, with Helichrysum, Lavender, German Chamomile and Geranium essential oils added. For use, mix equal parts of the jojoba and aloe first. Then, blend equal amounts of the four essential oils and add the synergy at a 2.5% dilution, basically using 15 drops of the essential oil blend to one ounce of blended jojoba and aloe gel. Since the Aloe and the Jojoba will not blend, the mixture will need to be shaken well before each use.
These are just a few suggestions for cancer patients, their friends & caregivers, which might be helpful along the healing journey. For more information about aromatherapy & essential oils, see: www.naturesgift.com.

Cancer

Aromatherapy Support for Cancer Patients

Posted by kgshah on

Aromatherapy Support for Cancer Patients

Friends and family members of those fighting cancer often turn to aromatherapy & other types of alternative healing for help and support. It can be extremely frustrating to want to help a friend or loved one battling this terrible disease while feeling powerless to do so. Although certain essential oils (among them Frankincense, a rare species of Cypress, certain varieties of Thyme and Sage, and Lemongrass) have shown possible anti-tumor effects in some laboratory tests & research, to make any claims that essential oils can provide a cure for cancer is at the very least irresponsible and cruel.
What the oils can do, however, is strengthen the spirit, and provide emotional and spiritual support, both for the patient and for family members and caregivers. Essential oils are also being used to alleviate painful side effects of radiation & chemotherapy in cancer patients.
For strengthening the spirit, of particular usefulness are: Frankincense, Rose, & Atlas or Himalayan Cedarwood to spiritually uplift & promote emotional courage & strength. Further, Sandalwood oil, perhaps blended with either Cedarwood or Rose, can be emotionally supportive and comforting. Also, blends of citrus oils or conifers, diffused in the room, or used as an airborne spray does a wonderful job of both lifting the spirits, and removing “sickroom” odors. Some possible choices are: Pink Grapefruit, Sweet Orange, Red Mandarin, or Scotch Pine, Balsam Fir, Cypress, or Juniper.
Health care providers in America are becoming more open to the benefits of the holistic approach in caring for patients, with some adding aromatherapy programs as an element of treatment. This was the case when Nature’s Gift Aromatherapy was recently asked to provide a blend for a hospice in Montana as part of the facilities newly approved aromatherapy program. The nurse aromatherapist who commissioned the blend recommended using it with a gentle hand or foot massage. The blend consisted of 10 drops each of Somalian distilled Frankincense, and Frankincense CO2 extracted, with just 5 drops of Rose Otto 10% dilution. This would be the equivalent of 40 drops of Frankincense to 1 drop of undiluted Rose Otto. The blend may be diffused in an aroma lamp or diffuser or diluted way down (a 1% dilution, 6 drops of the blend to one fluid ounce of carrier oil or lotion) for massage.
On a physical level, positive results are being reported in dealing with post radiation pain and burning by using a blend of Jojoba oil and Aloe Vera gel, with Helichrysum, Lavender, German Chamomile and Geranium essential oils added. For use, mix equal parts of the jojoba and aloe first. Then, blend equal amounts of the four essential oils and add the synergy at a 2.5% dilution, basically using 15 drops of the essential oil blend to one ounce of blended jojoba and aloe gel. Since the Aloe and the Jojoba will not blend, the mixture will need to be shaken well before each use.
These are just a few suggestions for cancer patients, their friends & caregivers, which might be helpful along the healing journey. For more information about aromatherapy & essential oils, see: www.naturesgift.com.

Cancer

A Man’s Type of Woman

Posted by kgshah on

A Man’s Type of Woman

Believe it or not the Venus sign and Moon sign that is in a man’s chart actually describes what type of woman he is looking for in his life. He may not be aware of the type of woman he is looking for by his Venus sign. He will just find a pattern of specific women coming into his life. Below you will read the different Venus and Moon signs and how it affects a man and the type of woman he seeks.
Venus/Moon in Aries- This guy seeks a love-at-first-sight type of love relationship. He wants to feel the rush in a relationship. He will fall in love fast but can also fall out of love just as quick. He wants an adventurous woman. She needs to keep him on his toes and always find something new and spontaneous to do or he will get bored easily. He may end up with several short relationships and marriages. Elizabeth Taylor has this Venus sign in her marriage house.
Venus/Moon in Taurus- Taurus is the ruling planet of Venus. They are devoted and seek a woman who is devoted to her partner. Venus in Taurus men want love to be there and won’t settle for anything less. They want marriages, dedication and always seek loyalty. They may attract a stubborn woman but will also seek a woman who works hard for their money. This man may also look for a woman who is full-figured and enjoys cooking. He may enjoy spending more time at home than going out on dates.
Venus/Moon in Gemini- Communication is the key when this man is seeking a woman. He also will check out her hands and how she expresses herself. He wants a woman who will communicate with her. He will also like a woman who will be flirty with her words. He may easily like this woman to have a sexy voice or talk dirty to him during intimate moments.
Venus/Moon in Cancer- This man seeks a woman who loves the home. She also needs to be nurturing and supportive. He seeks a woman who may have many of his mother’s traits or could even be a mama’s boy. He will have a close tie to his mother and expects you to have a close tie to yours. He may expect you to have a close tie to his mother too. He will be home-bodied and have many gathering at home.
Venus/Moon in Leo- This man wants his woman to always take care of her appearance. Her clothes need to be neat and organized and she always needs to be stylish. He will seek a woman who maintains her beauty with makeup. Her hair is always styled and she seeks to be on top of the latest fashions. He may attract a woman who is dramatic or easily attracts drama. She may be in the entertainment field. He also may be attracted to a woman with children.
Venus/Moon in Virgo- He is attracted to a woman who is neat and organized. She needs to be clean and tidy with day to day routine. This man is also picky with his woman. He may always find something wrong with every woman he dates or fall sin love with. He is shy and may easily have woman introduce themselves to him. He attracts woman easily because of his shy exterior. He is a family man who does seek love and affection from his woman and children.
Venus/Moon in Libra- Libra is the ruling planet of Venus. He loves to be in love. He cannot be alone and chooses to be with women regularly. If he is alone then he can easily be depressed of being alone. He loves to receive affection and attention even if he is with another woman. He is devoted to his lover but can easily send off the wrong message to other women. They may think he is attracted to them and pursue him. Venus in Libra men are devoted to their women and will do anything to make them happy.
Venus/Moon in Scorpio- This is a man who gives passionately to his woman. He will be committed and devoted to her. The bad traits are that he may be jealous and possessive of her. He seeks a woman who has a karmic intense connection with him. He gives all and expects the same from her. She needs to be always available to him or else he may get jealous. He may be controlling and manipulative. This is a man who may like leather and latex or to experiment sexually. Any woman who gets involved with a Venus in Scorpio male must be open minded.
Venus/Moon in Sagittarius-The explorer. This man will be open to being with a woman who is from different culture or from a foreign country. She needs to be open to travel and adventure. He wants his space so expect to give him plenty of it. He likes to try something new and may be open to new adventures. Exercise and sports are important to him or he may always expect for you to be in good health. Take chances with this man as he wants his woman to take chances with him. This man will enjoy a woman who loves to learn something new on a regular basis.
Venus/Moon in Capricorn- Devotion and dedication are keywords of this man. He seeks a woman who is good with her money or knows how to make money. He seeks a woman whom he knows will always be devoted and loyal to him. Commitment is another word to describe him. He expect his woman to be the same way. He will be a great provider to the right woman. He may seek a woman in business or who runs her own business.
Venus/Moon in Aquarius- He wants his woman to be his friend. He may find love among his friends too. He also seeks space and the ability to come and go freely. He will be devoted to you but you need to trust him. He is open to long distance relationships. He may be eccentric or find a woman who is eccentric herself. He also seeks a woman who can talk provocatively to him. Words turn him on. He wants to have his space and will be comfortable giving you space too. His friends are important to him so he will wants to spend time with them regularly.
Venus/Moon in Pisces- He if full of romance. He seeks a woman who is his soul mate and is very spiritual herself. He wants to feel a strong karmic connection to her. This man may have some codependency issues so be careful. He may attract a woman who is codependent on him or may have an addiction problem. He is artistic or may attract a woman who is artistic herself. This man is devoted may seek the love and affection of another if he feels neglected. Give him plenty of love and he will do the same for you too.

Cancer

Bad Vibes Dowse Your House

Posted by kgshah on

Bad Vibes Dowse Your House

*** Bad Vibes? Dowse Your House

Have you ever walked into a home or a business and felt it had bad vibes? Although you probably couldn’t quite put your finger on it, you knew something wasn’t right. More than likely, you tried to get out of there as fast as you could because you weren’t comfortable there.
Our bodies are very much in tune with what’s going on in our environment, whether we can see it or not. When the environment isn’t healthy, we know it at a subconscious level and react at a conscious level. This negative feeling is like a static charge that builds as we walk through the home or office building. Only instead of getting a physical shock when this charge reaches its peak, we get a shock to our psyche.
So, what is this negative charge or energy that we’re picking up on? It’s both natural and man-made. There are a number of different kinds of energy that, when concentrated, create that get me out of here’s sensation inside of us. These energies include Geo pathetic stress, negative Hartman lines, negative Curry lines and interference lines. There are others, as well and they each have their own origins and unique characteristics.
Geopathic stress literally means disease of the earth: ‘earth’ (geo) ‘disease’ (pathic). These stress areas in the earth are caused by fault lines, underground cavities, certain mineral concentrations under the earth and even underground water. You can see the effects of geopathic stress in the cracks in your sidewalk and driveway, and cracked tiles on the floor. Geopathic stress is also what causes earthquakes.
Hartman lines are different. These were discovered by a German physician named Ernst Hartman in the early 1940s. Hartman lines are sometimes referred to as the Earth’s electrical grid or nervous system. These lines run from North to South and East to West. These lines are naturally occurring and by themselves are not harmful. However, when electric outlets, fuse boxes or transformers are situated on these lines the electrical contact can cause the energy in the Hartman lines to turn negative and it’s this negative energy that causes us harm.
Dr. Hartmann discovered these lines and their negative effects when he began to see more and more patients coming to his practice with what were uncommon diseases for the 1940s like liver disease and cancer. After visiting these patients’ homes and offices, he found that they were either sleeping or sitting at a point where one or more negative Hartmann lines were located. The point on their body where the disease resided coincided with the location that the negative Hartmann line was crossing on their bodies.
Curry lines were discovered about ten years after Hartman lines by Dr. Manfred Curry and Dr. Whitman. These lines, like Hartman lines, are naturally occurring and part of the Earth’s electric grid. Curry lines run through the earth at diagonal angles from Northwest to Southeast and from Northeast to Southwest. Just like Hartman lines, the energy in Curry lines become negative when they are affected by electric outlets, fuse boxes or transformers.
Interference lines were discovered about a decade ago with the addition of cell phone towers to our landscape. Like AM and FM radio, cell phone towers have a specific frequency they send out so customers can communicate with each other. Interestingly enough, the organs in your body each have their own unique frequency as well. As these towers were being put up it was discovered that the frequency being sent out by some of these cell towers coincided with the frequency generated by specific body organs.
In one instance, a woman in California had her home’s energy evaluated because it just didn’t feel right to her. The gentleman who conducted the evaluation asked her whether anyone in her family had problems with their liver. She said it was odd that he asked because the entire family had just had complete physicals done three weeks before. The blood tests that came back indicated they all had signs of early stage liver disease. She said it came as a shock to them because no one on either side of the family had a history of liver problems.
The gentleman said that he wasn’t surprised because the frequency being transmitted by the cell phone tower 3 miles from their home was the same frequency as that of the liver. He said he had discovered this when several other families in the area he had worked with all told him they had liver problems too.
When geopathic stress, negative Hartmann lines, negative Curry lines or interference lines have an excessive presence in a home or office building they can give you that bad vibe feeling. In smaller doses the effects are more subtle and can range from feeling angry, frustrated or upset to creating physical aches and pains in the same area of your body over and over again. You may even find that your home or office has excessive amounts of clutter in certain spots as you subconsciously try to bury this energy under piles of paper and magazines.
The good news is that you can block this energy from entering your space by having your home or office dowsed. A good dowser can tell you what the energy level of your home or office is using their dowsing rods, can dowse your property and building to block the stress lines and other negative energy from coming into your space and then tell you what the energy is once their done. Think of this as acupuncture for your home or office.
One of the great things about dowsing your home or office is that the change takes place instantly. In fact, your body will react to this shift by making you more tired and/or thirsty for a couple of days so be sure to get plenty of rest and stay hydrated. If you’ve ever been to a massage therapist they tell you to do the same thing because they are shifting the energy in your body and releasing the toxins through their massage technique. Dowsing has this same effect for your home and office.
If you practice Feng shui your activation’s and cures will work even better if you dowse first. As an added bonus you’ll feel much better, too.